Issue 19, 2009
From the journal:

Organic & Biomolecular Chemistry

A colorimetric and fluorescent merocyanine-based probe for biological thiols†

Shu-Ping Wang,a   Wu-Jian Deng,a   Dan Sun,a   Min Yan,a   Hong Zheng*a  and  Jin-Gou Xua  

* Corresponding authors

a Department of Chemistry and The Key Laboratory of Analytical Sciences of MOE, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China
E-mail: hzheng@xmu.edu.cn

Abstract

A new “dual-mode” chromogenic and fluorescent turn-on probe (2) for the selective sensing of biological thiols is reported. In MeOH–H2O cosolvent at physiological pH 7.40 (MeOH–H2O = 3:7), biological thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the chromo- and fluorophore merocyanine (3).

Graphical abstract: A colorimetric and fluorescent merocyanine-based probe for biological thiols

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Article information

DOI
https://doi.org/10.1039/B909760K
Article type
Paper
Submitted
19 May 2009
Accepted
09 Jul 2009
First published
10 Aug 2009

Org. Biomol. Chem., 2009,7, 4017-4020

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A colorimetric and fluorescent merocyanine-based probe for biological thiols

S. Wang, W. Deng, D. Sun, M. Yan, H. Zheng and J. Xu, Org. Biomol. Chem., 2009, 7, 4017 DOI: 10.1039/B909760K

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