Issue 21, 2008
From the journal:

Organic & Biomolecular Chemistry

Phosphinates as new electrophilic partners for cross-coupling reactions†

Jun Guo,a   John D. Harling,b   Patrick G. Steel*a  and  Tom M. Woodsa  

* Corresponding authors

a Department of Chemistry, University of Durham, Science Laboratories, South Road, DH1 3LE, Durham, UK
E-mail: p.g.steel@durham.ac.uk

b GlaxoSmithKline, Gunnels Wood Road, SG1 2NY, Stevenage, Herts, UK

Abstract

The use of enol phosphinates as electrophiles for cross-coupling reactions has been explored. Both boronic acids (Suzuki–Miyaura reaction) and stannanes (Stille reaction) couple efficiently with lactam derived phosphinates.

Graphical abstract: Phosphinates as new electrophilic partners for cross-coupling reactions

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Article information

DOI
https://doi.org/10.1039/B809577A
Article type
Paper
Submitted
05 Jun 2008
Accepted
22 Aug 2008
First published
15 Sep 2008

Org. Biomol. Chem., 2008,6, 4053-4058

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Phosphinates as new electrophilic partners for cross-coupling reactions

J. Guo, J. D. Harling, P. G. Steel and T. M. Woods, Org. Biomol. Chem., 2008, 6, 4053 DOI: 10.1039/B809577A

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