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Abstract | Cited by

The desymmetrisation of prochiral α,α-dicyanoalkenes via tandem Michael–Michael addition reactions with α,β-unsaturated ketones catalysed by 9-amino-9-deoxyepicinchona alkaloids was investigated, from which bicyclic products bearing four stereogenic centers were afforded in a single operation with high stereoselectivities (>99% de, up to >99.5% ee).

Graphical abstract: Stereoselective desymmetrisation of prochiral α,α-dicyanoalkenes via domino Michael–Michael addition reactions

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