Issue 7, 2008
From the journal:

Organic & Biomolecular Chemistry

Highly enantioselective alkynylation of aldehydes catalyzed by a new oxazolidine–titanium complex†

Zhou Xu,a   Jincheng Mao*a  and  Yawen Zhang*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou (Soochow) University, Suzhou, China
E-mail: jcmao@suda.edu.cn

Abstract

The readily available and inexpensive new chiral oxazolidine 2a in combination with Ti(OiPr)4 was found to catalyze the reaction of an alkynylzinc reagent with various types of aldehydes to generate chiral propargylic alcohols with high enantioselectivities (up to 95%) and excellent yields (up to 98%).

Graphical abstract: Highly enantioselective alkynylation of aldehydes catalyzed by a new oxazolidine–titanium complex

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Article information

DOI
https://doi.org/10.1039/B719624E
Article type
Paper
Submitted
20 Dec 2007
Accepted
30 Jan 2008
First published
22 Feb 2008

Org. Biomol. Chem., 2008,6, 1288-1292

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Highly enantioselective alkynylation of aldehydes catalyzed by a new oxazolidine–titanium complex

Z. Xu, J. Mao and Y. Zhang, Org. Biomol. Chem., 2008, 6, 1288 DOI: 10.1039/B719624E

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