Carl F. Nising and Stefan Bräse
Chem. Soc. Rev., 2008,37, 1218-1228
DOI:
10.1039/B718357G,
Tutorial Review
In marked contrast to Michael reactions, oxa-Michael reactions have not been used as standard transformations in organic synthesis until quite recently. This was mainly due to a lack of reactivity and selectivity, although the potential products of such reactions are valuable intermediates. This tutorial review presents recent major advances in the field of oxa-Michael (sometimes called oxo-Michael or oxy-Michael) reactions and applications in the total synthesis of complex natural products.
