Issue 14, 2008
From the journal:

Chemical Communications

Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?†

Tomislav Friščić,a   László Fábián,b   Jonathan C. Burley,c   David G. Reid,d   Melinda J. Duerd  and  William Jones*a  

* Corresponding authors

a Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: wj10@cam.ac.uk
Fax: +44(0) 1223 336017
Tel: +44(0) 1223 336 343

b Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, UK

c School of Pharmacy, The University of Nottingham, Boots Science Building, University Park, Nottingham, UK

d Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

Abstract

Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

Graphical abstract: Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?

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Article information

DOI
https://doi.org/10.1039/B717532A
Article type
Communication
Submitted
13 Nov 2007
Accepted
04 Jan 2008
First published
30 Jan 2008

Chem. Commun., 2008, 1644-1646

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Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?

T. Friščić, L. Fábián, J. C. Burley, D. G. Reid, M. J. Duer and W. Jones, Chem. Commun., 2008, 1644 DOI: 10.1039/B717532A

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