Surface-based lipidvesicle reactor systems: fabrication and applications

Abstract

Over the last ten years there has been a strong (bio)technological drive for the development of miniaturised reaction systems, motivated mainly by the need to reduce sample consumption and parallelise. Self-assembled soft-matter containers have naturally evolved to handle small volumes and could provide viable fluidic solutions especially in niche areas where ultra-miniaturisation, biocompatibility or cost are of critical importance. Here we focus on nanocontainers that are made of lipids and are immobilised on surfaces. We will highlight the most prominent contributions to date on the fabrication and the applications of surface-based vesicle systems as miniaturised reactors. Emphasis will be put on single-vesicle experiments.