Issue 28, 2007
From the journal:

Chemical Communications

A novel class of metal-directed supramolecular DNA-delivery systems†

Itzia Cruz-Campa,a   Alejandro Arzola,a   Lynn Santiago,a   Jason G. Parsons,a   Armando Varela-Ramirez,b   Renato J. Aguilerab  and  Juan C. Noveron*a  

* Corresponding authors

a Department of Chemistry, University of Texas, El Paso, TX, USA
E-mail: jcnoveron@utep.edu
Fax: +1 (915) 747-5748
Tel: +1 (915) 747-7572

b Department of Biological Sciences, University of Texas, El Paso, TX, USA

Abstract

The bis-complexes [Cu(Ldt)2](OTf)2 (1) and [Cu(Lot)2](OTf)2 (2), where Ldt = 1-dodecyl-1,4,7-triazacyclononane, Lot = 1-octadecyl-1,4,7-triazacyclononane and OTf = trifluoromethanesulfonate, formed a novel class of metallo-liposomes in water that transfect pEGFP-N1 plasmids into HEK 293-T cells at 38% and 4% efficiency, respectively.

Graphical abstract: A novel class of metal-directed supramolecular DNA-delivery systems

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Article information

DOI
https://doi.org/10.1039/B703201C
Article type
Communication
Submitted
02 Mar 2007
Accepted
19 Apr 2007
First published
09 May 2007

Chem. Commun., 2007, 2944-2946

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A novel class of metal-directed supramolecular DNA-delivery systems

I. Cruz-Campa, A. Arzola, L. Santiago, J. G. Parsons, A. Varela-Ramirez, R. J. Aguilera and J. C. Noveron, Chem. Commun., 2007, 2944 DOI: 10.1039/B703201C

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