Issue 21, 2006

Efficient and direct synthesis of poly-substituted indeno[1,2-b]quinolines assisted by p-toluene sulfonic acid using high-temperature water and microwave heating via one-pot, three-component reaction

Abstract

Reactions of aldehydes, 1,3-indanedione and enaminones were successfully carried out using p-toluene sulfonic acid (p-TsOH) as a catalyst and high-temperature water as a solvent under microwave irradiation. This method provided several advantages such as rapid reaction times, high yields, and a simple workup procedure. In addition, a possible mechanism to account for the reaction was proposed.

Graphical abstract: Efficient and direct synthesis of poly-substituted indeno[1,2-b]quinolines assisted by p-toluene sulfonic acid using high-temperature water and microwave heating via one-pot, three-component reaction

Supplementary files

Article information

Article type
Paper
Submitted
08 Aug 2006
Accepted
12 Sep 2006
First published
29 Sep 2006

Org. Biomol. Chem., 2006,4, 3980-3985

Efficient and direct synthesis of poly-substituted indeno[1,2-b]quinolines assisted by p-toluene sulfonic acid using high-temperature water and microwave heating via one-pot, three-component reaction

S. Tu, B. Jiang, J. Zhang, R. Jia, Y. Zhang and C. Yao, Org. Biomol. Chem., 2006, 4, 3980 DOI: 10.1039/B611462H

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