Recognition of creatinine by weak aromatic acids in solid phase along with their supramolecular network

Abstract

Aromatic acids and creatinine, an important blood metabolite, form well-defined crystalline ionic complexes. Their supramolecular architecture is formed not only by simple proton transfer and ionic interaction but also by other very important noncovalent interactions, especially the hydrogen bonds. The supramolecular behavior of the complexes is varied with the acidity and structural difference of aromatic acids. Creatinine interestingly generated creatine monohydrate during crystallization of creatinine with glacial acetic acid and the supramolecular array of creatine monohydrate is also reported.