Issue 40, 2006
From the journal:

Chemical Communications

Solution structures of thiopeptide antibiotics†

Richard J. Lewis,a   Rachael A. Hughes,b   Lilian Alcaraz,a   Stewart P. Thompsonb  and  Christopher J. Moody*bc  

* Corresponding authors

a AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire, UK

b Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK

c School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: c.j.moody@nottingham.ac.uk

Abstract

A detailed NMR study of the thiopeptide amythiamicin D establishes its solution conformation and the presence of a single intramolecular hydrogen bond involving NH13 and O28, and also provides the first evidence for self-association of thiopeptides in solution.

Graphical abstract: Solution structures of thiopeptide antibiotics

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Article information

DOI
https://doi.org/10.1039/B609282A
Article type
Communication
Submitted
30 Jun 2006
Accepted
03 Aug 2006
First published
24 Aug 2006

Chem. Commun., 2006, 4215-4217

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Solution structures of thiopeptide antibiotics

R. J. Lewis, R. A. Hughes, L. Alcaraz, S. P. Thompson and C. J. Moody, Chem. Commun., 2006, 4215 DOI: 10.1039/B609282A

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