Marie Bøjstrup and Inge Lundt
Org. Biomol. Chem., 2005,3, 1738-1745
DOI:
10.1039/B501824B,
Paper
Four aminocyclopentanols, as mimics of putative intermediates in the hydrolysis of α-D-galactosides, have been synthesized through a number of stereoselective transformations using the cis-fused cyclopentane-1,4-lactone (1R, 5S, 7R, 8R)-7,8-dihydroxy-2-oxabicyclo[3.3.0]oct-3-one 1 as a chiral building block. The compounds were tested towards various glycosidases but showed no anomer selectivity in the inhibition of α- and β-galactosidases.
