Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides

With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having the general formula Ac–Oxx–L-Xaa–OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac–L-Oxd–L-Ala–OBn was identified as the most promising compound by MS–ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.