Issue 27-28, 2005

Phosphorescent oxygen-sensitive materials for biological applications

Abstract

A number of macromolecular probes employing different carriers and a number of microparticular probes employing different oxygen sensitive dyes were fabricated, giving a panel of oxygen sensitive probes. The photophysical and oxygen sensing properties of these probes were examined comparatively. The probes were used successfully to monitor cellular oxygen uptake and their ability to overcome a number of problems associated with oxygen sensing in biological samples was assessed. Macromolecular probes proved sufficient in a number of cases, particularly where spectral solutions can resolve the interferences. However where physical interactions cause interference the added protection of the polymer in the particle based probes was required.

Graphical abstract: Phosphorescent oxygen-sensitive materials for biological applications

Article information

Article type
Paper
Submitted
02 Feb 2005
Accepted
25 Apr 2005
First published
09 May 2005

J. Mater. Chem., 2005,15, 2946-2951

Phosphorescent oxygen-sensitive materials for biological applications

C. O'Donovan, J. Hynes, D. Yashunski and D. B. Papkovsky, J. Mater. Chem., 2005, 15, 2946 DOI: 10.1039/B501748C

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