Issue 21, 2004
From the journal:

Chemical Communications

Novel C–C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to β-aryl-β-hydroxy α-amino acid frameworks†

Yuanhua Wang,a   Zhiyong Chen,a   Aiqiao Mia  and  Wenhao Hu*a  

* Corresponding authors

a Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China
E-mail: huwh@cioc.ac.cn

Abstract

Ammonium ylides generated in situ from α-diazo esters and amines in the presence of catalytic Rh2(OAc)4, undergo an aldol-type reaction with aldehydes affording highly substituted amino acid frameworks in a convergent, three-component reaction.

Graphical abstract: Novel C–C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to β-aryl-β-hydroxy α-amino acid frameworks

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Article information

DOI
https://doi.org/10.1039/B407449A
Article type
Communication
Submitted
17 May 2004
Accepted
13 Jul 2004
First published
14 Sep 2004

Chem. Commun., 2004, 2486-2487

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Novel C–C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to β-aryl-β-hydroxy α-amino acid frameworks

Y. Wang, Z. Chen, A. Mi and W. Hu, Chem. Commun., 2004, 2486 DOI: 10.1039/B407449A

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