Issue 14, 2004
From the journal:

Chemical Communications

New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization

Serge Cosnier,*a   Chantal Gondran,a   Cécile Dueymes,b   Philippe Simon,bc   Marc Fontecaveb  and  Jean-Luc Découtc  

* Corresponding authors

a Laboratoire d'Electrochimie Organique et de Photochimie Rédox UMR 5630 CNRS Institut de Chimie Moléculaire de Grenoble FR CNRS 2607, Université Joseph Fourier, BP 53, 38041 Grenoble cedex9, France
E-mail: serge.cosnier@ujf-grenoble.fr
Fax: +33 4 76 51 42 67
Tel: +33 4 76 51 49 98

b Laboratoire de Chimie et Biochimie des Centres Rédox Biologiques, UMR 5047 UJF/CEA/CNRS DRDC-CB, CEA Grenoble, 17 Avenue des Martyrs 38054, Grenoble Cedex 09, France

c Laboratoire de Chimie Bio-Organique, Département de Pharmacochimie Moléculaire, UMR 5063 CNRS/Université Joseph Fourier, FR CNRS 2607, BP 138, 5 Avenue de Verdun, F-38243 Meylan, France

Abstract

The functionalization of an oligonucleotide by flavin and deazaflavin derivatives allowed an amperometric determination of the hybridization process through the disappearance of the electroactivity of the free oligonucleotide and the appearance of a new electrochemical signal characteristic of the resulting duplex.

Graphical abstract: New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization

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Article information

DOI
https://doi.org/10.1039/B402760D
Article type
Communication
Submitted
23 Feb 2004
Accepted
28 Apr 2004
First published
15 Jun 2004

Chem. Commun., 2004, 1624-1625

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New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization

S. Cosnier, C. Gondran, C. Dueymes, P. Simon, M. Fontecave and J. Décout, Chem. Commun., 2004, 1624 DOI: 10.1039/B402760D

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