All the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine – a key constituent of the potential antitumor agent belactosin A – were prepared by simple catalytic hydrogenation of (2S,1'S,2'S)-, (2S,1'R,2'R)-, (2R,1'R,2'R)-, and (2R,1'S,2'S)-3-(trans-2-nitrocyclopropyl)alanines in 95, 93, 91 and 92% yields, respectively.
Rational synthesis of all the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine
O. V. Larionov, S. I. Kozhushkov, M. Brandl and A. de Meijere, Mendeleev Commun., 2003, 13, 199 DOI: 10.1070/MC2003v013n05ABEH001817
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