Issue 15, 2003
From the journal:

Chemical Communications

A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N,P-ligands for copper-catalysed conjugate addition†

Andrei V. Malkov,*a   John B. Handa  and  Pavel Kočovský*a  

* Corresponding authors

a Department of Chemistry, University of Glasgow, Glasgow, UK
E-mail: amalkov@chem.gla.ac.uk, P.Kocovsky@chem.gla.ac.uk

Abstract

New N,P-ligands 4–6, derived from valinol and prolinol, respectively, have been developed for the asymmetric, copper(I)-catalysed conjugate addition of diethylzinc to unsaturated ketones; the tertiary amide group has been shown to effectively relay the chiral information from the ligand backbone to the active centre.

Graphical abstract: A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N,P-ligands for copper-catalysed conjugate addition

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Article information

DOI
https://doi.org/10.1039/B304131J
Article type
Communication
Submitted
14 Apr 2003
Accepted
16 Jun 2003
First published
30 Jun 2003

Chem. Commun., 2003, 1948-1949

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A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N,P-ligands for copper-catalysed conjugate addition

A. V. Malkov, J. B. Hand and P. Kočovský, Chem. Commun., 2003, 1948 DOI: 10.1039/B304131J

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