The preparation of thiophene-based azacryptand Mannich bases
Abstract
The preparation of cryptand-like structures, incorporating four thiophene rings, was undertaken. A variety of approaches were considered, but a stepwise process commencing from the readily available α,ω-bis(2-formyl-3-thienyloxy)alkanes of the type ArO-Z-OAr (where Ar = 2-formyl-3-thienyl and Z
= heteroalkyl chain) yielded excellent results. A range of open chain and cyclic Mannich bases incorporating one or two macrorings was prepared via