Issue 23, 2002
From the journal:

Chemical Communications

Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether–poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry†

Béla Török,a   Imre Bucsi,a   G. K. Surya Prakash*a  and  George A. Olah*a  

* Corresponding authors

a Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA
E-mail: gprakash@usc.edu

Abstract

The newly developed stable DMEPHF (1/15) complex was found to be a highly effective reagent for the cleavage of peptides from Merrifield resins; ease of handling and its simple, complete removal from the reaction mixture make the reagent system a very useful HF equivalent for applications in solid-phase peptide synthesis.

Graphical abstract: Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether–poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry

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Article information

DOI
https://doi.org/10.1039/B206168F
Article type
Communication
Submitted
20 Jun 2002
Accepted
18 Oct 2002
First published
04 Nov 2002

Chem. Commun., 2002, 2882-2883

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Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether–poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry

B. Török, I. Bucsi, G. K. S. Prakash and G. A. Olah, Chem. Commun., 2002, 2882 DOI: 10.1039/B206168F

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