Issue 11, 2002
From the journal:

Chemical Communications

A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

Guolin Li,a   Ricky Mehta,a   Thamarapu Srikrishnan,b   Daniel J. Nurco,c   Walter A. Tabaczynski,b   James L. Alderfer,b   Kevin M. Smith,c   Thomas J. Doughertya  and  Ravindra K. Pandey*a  

* Corresponding authors

a Chemistry Division, PDT Center, and Nuclear Medicine

b Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

c Department of Chemistry, University of California, Davis, CA 95616

Abstract

Reaction of meso-(2-formylvinyl)octaethylporphyrin with (CH3)3SiCN–Cu(OTf)2 produced unexpected 103-trimethylsiloxyl and 103-hydroxyl fused propenochlorins which, in H2SO4, underwent subsequent migration of the 8-ethyl group to the 103-position of the exocyclic benzene ring to form a novel benzochlorin.

Graphical abstract: A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

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Article information

DOI
https://doi.org/10.1039/B202280J
Article type
Communication
Submitted
28 Feb 2002
Accepted
12 Apr 2002
First published
29 Apr 2002

Chem. Commun., 2002, 1172-1173

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A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

G. Li, R. Mehta, T. Srikrishnan, D. J. Nurco, W. A. Tabaczynski, J. L. Alderfer, K. M. Smith, T. J. Dougherty and R. K. Pandey, Chem. Commun., 2002, 1172 DOI: 10.1039/B202280J

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