Issue 3, 2002
From the journal:

Chemical Communications

Polyclonal antibody-catalysed hydrolysis of a β-lactam

Elizabeth L. Ostler,a   Marina Resmini,b   Guillaume Boucher,a   Nickolas Romanov,c   Keith Brocklehurstd  and  Gerard Gallacher*a  

* Corresponding authors

a School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, UK
E-mail: g.gallacher@bton.ac.uk

b Department of Chemistry, Queen Mary, University of London, Mile End Rd, London, UK

c Erevanskkaya 14-a, K25, Kiev-87, Ukraine

d Laboratory of Structural and Mechanistic Enzymology, School of Biological Sciences, Queen Mary, University of London, Mile End Rd, London, UK

Abstract

We report the first example of antibody-catalysed hydrolysis of a β-lactam where the antibodies were generated by a simple transition-state analogue; in this example the antibodies are polyclonal.

Graphical abstract: Polyclonal antibody-catalysed hydrolysis of a β-lactam

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Article information

DOI
https://doi.org/10.1039/B110135H
Article type
Communication
Submitted
06 Nov 2001
Accepted
13 Dec 2001
First published
14 Jan 2002

Chem. Commun., 2002, 226-227

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Polyclonal antibody-catalysed hydrolysis of a β-lactam

E. L. Ostler, M. Resmini, G. Boucher, N. Romanov, K. Brocklehurst and G. Gallacher, Chem. Commun., 2002, 226 DOI: 10.1039/B110135H

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