Unifying the mechanisms for alkane dehydrogenation and alkene H/D exchange with [IrH2(O2CCF3)(PAr3)2]: the key role of CF3CO2 in the “sticky” alkane route
Abstract
To
understand photochemical and thermal alkane activation with IrH2(O2CCF3)(PAr3)2 (Ar =
p-FC6H4), H/D isotope
scrambling between alkenes and IrD2(O2CCF3)(PAr3)2 was studied. No unique interpretation
of the experimental data was possible, so DFT(B3PW91) calculations on the exchange process in Ir(H)2(O2CCF3)(PH3)2(C2H4) were carried out to distinguish between the possibilities allowed by experiment. Of several possible
mechanisms for H/D scrambling, one was strongly preferred and is therefore proposed here. It involves the insertion
of the olefin to give an alkyl hydride that reductively eliminates to lead to a transition state that contains
an η3-bound alkane. This transition state, which achieves a 1,1′ geminal H/D exchange, is significantly lower in energy
than a dihydrido carbene, located as a secondary minimum, eliminating the alternative carbene mechanism.
The unexpectedly large binding energy (BDE) of the alkane (“sticky alkane”) to the Ir(O2CCF3)(PH3)2 fragment (BDE = 11.9
kcal mol−1) in this transition state is ascribed in part to the presence of a weakly σ- and π-donating (CF3CO2) group trans
to the alkane binding site. The H/D exchange selectivity observed requires that 1,1′-shifts (i.e., M moving to
a geminal C–H bond), but not 1,3-shifts, be allowed in the alkane complex. In a key finding, a 1,3-shift in which
the metal moves down the alkane chain is indeed found to have a much higher activation energy than the 1,1′-process
and is therefore slow in our system. A 1,2-shift has not been considered since it would involve a strong steric hindrance
at a tertiary carbon in this system. The mechanism ia an alkane path provides an insight into the
closely related photochemical and catalytic thermal alkane dehydrogenation processes mediated by IrH2(O2CCF3)(PAr3)2; the thermal route requires tBuCH
CH2 as the hydrogen acceptor. These two alkane reactions are intimately
related mechanistically to the isotope exchange because they are proposed to have the same intermediates,
in particular the sticky alkane complex. Remarkably, the rate determining step of the thermal (150 °C) alkane dehydrogenation
process is predicted to be substitution of the hydrogen acceptor-derived
alkane by the alkane substrate.