Issue 6, 2001

Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate

Abstract

Paclitaxel-containing aminoester phosphate 4 and phosphoamidate 9 were synthesised and found to possess anticancer activity against HL-60 leukemia cells; their solubility in a phosphate buffer solution was about 16 times higher than that of paclitaxel.

Article information

Article type
Paper

Mendeleev Commun., 2001,11, 216-217

Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate

J. R. Hwu, S. Tsay, T. Sambaiah, Y. Lai, C. Lieu, G. H. Hakimelahi and K. King, Mendeleev Commun., 2001, 11, 216 DOI: 10.1070/MC2001v011n06ABEH001498

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