β-Glycosidase inhibitors mimicking the pyranoside boat conformation
Abstract
Polyhydroxylated isoquinuclidines mimicking the boat conformation of pyranosides are strong and selective inhibitors of a retaining β-mannosidase.
* Corresponding authors
a
Laboratorium für Organische Chemie, ETH-Zentrum, Universitätstrasse 16, Zürich, Switzerland.
E-mail:
vasella@sugar.org.chem.ethz.ch
Polyhydroxylated isoquinuclidines mimicking the boat conformation of pyranosides are strong and selective inhibitors of a retaining β-mannosidase.
β-Glycosidase inhibitors mimicking the pyranoside boat conformation
E. Lorthiois, M. Meyyappan and A. Vasella, Chem. Commun., 2000, 1829 DOI: 10.1039/B005578F
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