Markus Kosonen, Raimo Seppänen, Oula Wichmann and Harri Lönnberg
βrg Values (rg = remnant group) for the O2′⇆O3′ isomerization of asymmetric dialkyl esters of 5′-O-pivaloyluridine 3′-phosphate and βlg values (lg = leaving group) for the cleavage of the more electronegative alkoxy group from these triesters under various conditions have been determined. The reactions studied included hydronium ion, hydroxide ion, general acid and general base, and pH- and buffer-independent cleavage. The results are compared with the corresponding values obtained earlier with the symmetric 3′-triesters and the catalysis mechanisms are discussed.