Synthesis, structural characterization and antioxidative properties of aminopyrazine and imidazolopyrazine derivatives

Abstract

The reaction of 2-aminopyrazine 1 with the glyoxal derivatives 2a–c gave the bicyclic imidazolopyrazinones 3a,b and the monocyclic N-substituted aminopyrazines 4b and 5c. Compounds 3 feature unique crystallographic characteristics. Their reactivity towards superoxide anion is about five times the reactivity of Trolox^®, while the monocyclic pyrazines are inactive.

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