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DOI: 10.1039/A900286C (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 2, 1999, 1175-1180

Synthesis and stereochemistry of β-aryl-β-haloacroleins: useful intermediates for the preparation of (Z[hair space]) and (E[hair space])-2-en-4-ynecarbaldehydes and for the synthesis of rubrolides

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Damien Prim, Alexia Fuss, Gilbert Kirsch and Artur M. S. Silva

Abstract

The synthesis of α-substituted β-aryl-β-haloacroleins by two different pathways is presented. The determination of their stereochemistry by NOE experiments is reported for the first time. Furthermore, we describe the preparation of 2-en-4-ynecarbaldehydes and access to rubrolide derivatives from β-aryl-β-haloacroleins.

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