Enantioselective synthesis of α-hydroxysilanes by bioreduction of aroyltrimethylsilanes

Abstract

Aromatic acylsilanes [Ar-CO-SiMe₃; Ar = C₆H₅, 4-ClC₆H₄, 2-, 3- and 4-OMeC₆H₄, 3,4-(OMe)₂C₆H₃ and 3,4-OCH₂OC₆H₃] were reduced by baker’s yeast to optically active α-silyl alcohols in 20–70% yield and 43–88% ee. Comments are made on the influence of silicon in this bioreduction reaction.

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