Synthetic studies on the glycosylation of the base residues of inosine and uridine

Abstract

Ribosylation and glucosylation of the base residues of inosine and uridine have been efficiently achieved using Mitsunobu reaction, leading to the N-1 and 6-O-glycosylinosine and N-3-glycosyluridine derivatives, all with β configuration at the glycosidic carbon. The unprecedented 5-amino-1-(β-D-ribofuranosyl)imidazole-4-[N-(β-D-glucopyranosyl)carboxamide] has also been synthesised.

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