High yielding synthesis of dehydroamino acid and dehydropeptide derivatives

Abstract

By using a 4-dimethylaminopyridine (DMAP) catalysed reaction of β-hydroxyamino acid derivatives with tert- butyl pyrocarbonate [(Boc)₂O], dehydroamino acid derivatives are obtained in high yields. The same methodology applied to dipeptides with a β-hydroxyamino acid residue gives the corresponding dipeptides with a dehydroamino acid residue.

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