Synthesis of analogues of the marine anti-tumour agent curacin A

Abstract

A concise, multigram synthesis of (4R)-2-[(1′R,2′S )-1′,2′-methano-3′-(tert-butyldiphenylsiloxy)propyl]-4-hydroxymethyl-4,5-dihydrothiazole has been achieved, and this compound has been used for the production of a range of analogues of the anti-mitotic agent curacin A.

References

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