DOI: 10.1039/A901123D
(Paper)
J. Chem. Soc., Perkin Trans. 1, 1999, 1147-1150
Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β
(Note: The full text of this document is currently only available in the PDF Version )
Jing-Zhen Deng, Di-An Sun, Shelley R. Starck, Sidney M. Hecht, Ronald L. Cerny and John R. Engen
Abstract
Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 µM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl m-methylhydroquinone occurring in a higher terrestrial plant.