The synthesis of 1,8-dihydroxynaphthalene-derived natural products: palmarumycin CP₁, palmarumycin CP₂, palmarumycin C₁₁, CJ-12,371, deoxypreussomerin A and novel analogues

Abstract

Total syntheses of the title fungal metabolites are described via a route which utilises initial acetalisation with 1,8-dihydroxynaphthalene followed by elaboration of the ring A functionality. Novel analogues are also reported. Structural clarification is provided for palmarumycin C₁₁, bipendensin and Sch 53,823.

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