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DOI: 10.1039/A900800D (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1999, 969-978

The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents

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Michael G. B. Drew, Stephen Gorsuch, Jayne H. M. Gould and John Mann

Abstract

(5S[hair space])-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H[hair space])-one has been converted into cytosine 2′,3′-dideoxy-3′,5′-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.

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