Synthetic approaches towards phorbols via the ultra-high-pressure mediated intramolecular Diels–Alder reaction of furans (IMDAF): effect of furan substitution

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Angela C. Brickwood, Michael G. B. Drew, Laurence M. Harwood, Tsutomu Ishikawa, Pierre Marais and Véronique Morisson


Abstract

Tricyclic structures having the functionality and stereochemistry inherent in phorbol and its analogues may be rapidly constructed by an ultra-high pressure IMDAF reaction. The nature of the 2-thioether substituent on the furan diene is critical for the success of the key cycloaddition reaction.


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