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DOI: 10.1039/A808780F (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1999, 271-278

Lipase-mediated synthesis of the enantiomeric forms of 4,5-epoxy-4,5-dihydro-α-ionone and 5,6-epoxy-5,6-dihydro-β-ionone. A new direct access to enantiopure (R)- and (S[hair space])-α-ionone

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Josefina Aleu, Elisabetta Brenna, Claudio Fuganti and Stefano Serra

Abstract

Stereoselective lipase-mediated esterifications of epoxy-α-ionol 5 and epoxy-β-ionol 9 afforded suitable precursors of the enantiomers of the corresponding oxidised derivatives epoxy-α-ionone 3 and epoxy-β-ionone 4. An interesting development of this work is the easy conversion of enantiopure 3a and 3b into highly valuable enantiopure (S[hair space])- and (R)-ionone (1a and 1b) via a mild deoxygenation reaction.

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