DOI: 10.1039/A808360F
(Paper)
Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1999, 721-726
On the preparation of 2-substituted cephalosporin sulfoxides via anionic intermediates
(Note: The full text of this document is currently only available in the PDF Version )
László Tamás, Tamás E. Gunda and Ferenc Sztaricskai
Abstract
The LDA-generated anions of cephalosporin sulfoxides may give rise to a mixture of C-2- and/or C-4-substituted products owing to the delocalized nature of the negative charge. Under optimized conditions 2α-crotonoyl- and 2α-cinnamoylcephalosporin sulfoxides can be obtained in satisfactory yields, and are useful starting materials for cycloaddition reactions leading to novel analogues with β-lactamase or HLE enzyme-inhibiting properties.
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