Asymmetric synthesis of (2R,3S )-2,3-epoxyamides via camphor-derived sulfonium ylides

Abstract

Enantiomerically enriched trans-2,3-epoxyamides 3 were prepared by the reaction of aldehydes 2 with camphor-derived chiral sulfonium ylide 1 in good yields and moderate to good ee values. The absolute configuration of the reaction product is also determined by chemical transformations.

References

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