Medium-sized Cyclophanes. Part 49. O-Alkylation of 8,16-Dihydroxy[2.2]metacyclophane

Abstract

O-Alkylation of 8,16-dihydroxy[2.2]metacyclophane 1 with alkyl halides in the presence of K₂CO₃ affords the mono-O-alkylated product 2; similar reaction in the presence of Cs₂CO₃ or NaH affords dialkylated product 3 in almost quantitative yield.

References

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