DOI: 10.1039/A902526J
(Paper)
Reference Section for: J. Chem. Res. (S), 1999, 414-415
Evidence of the Existence of 2:1 Guest–Host Complexes between Diclofenac and Cyclodextrins in D2O Solutions. A 1H and 13C NMR Study on Diclofenac/β-Cyclodextrin and Diclofenac/2-Hydroxypropyl-β-cyclodextrin Systems
(Note: The full text of this document is currently only available in the PDF Version )
Adele Mucci, Luisa Schenetti, Maria A. Vandelli, Barbara Ruozi and Flavio Forni
Abstract
The interaction of diclofenac sodium salt (DCFNa) and two cyclodextrins, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD), studied in D2O solution with different NMR techniques (1H, 13C NMR, ROESY experiments, NMR titrations), shows the existence of multiple equilibria involving 1:1 and 2:1 guest–host complexes.
References
- G. Wenz, Angew. Chem., Int. Ed. Engl., 1994, 33, 803 CrossRef.
- V. T. D'Souza and K. B. Lipkowitz, Chem. Rev., 1998, 98, 1741 CrossRef CAS.
- D. V. Whittaker, L. J. Penkler, L. A. Glintenkamp, M. C. B. van Oudtshoorn and P. L. Wessels, J. Incl. Phenom., 1996, 25, 177 CAS.
- S. Astilean, C. Ionescu, G. Cristea, S. I. Farcas, I. Bratu and R. Vitoc, Biospectroscopy, 1997, 3, 233 CrossRef CAS.
- M. R. Caira, V.-J. Griffith, L. R. Nassimbeni and B. van Oudtshoorn, J. Chem. Soc., Chem. Commun., 1994, 1061 RSC.
- M. Otagiri, T. Imai, N. Matsuo and K. Uekama, Acta Pharm. Suec., 1983, 20, 1 Search PubMed.
- F. Leroy-Lechat, D. Wouessidjeve, J. P. Andreux, F. Puisieux and D. Duchêne, Int. J. Pharm., 1994, 101, 97 CrossRef CAS.
- D. Neuhaus and M. P. Williamson, The Nuclear Overhauser Effect in Structural and Conformational Analysis, VCH, New York, 1989 Search PubMed.
- H. Takeshita, M. Kumamoto and I. Kouno, Bull. Chem. Soc. Jpn., 1980, 53, 1006.
- A. A. Bothner-BY, R. L. Stephens, J.-M. Lee, C. D. Warren and R. W. Jeanloz, J. Am. Chem. Soc., 1984, 106, 811 CrossRef CAS.