Synthesis of Phospholipids Bearing a Conjugated Oxo-polyunsaturated Fatty Acid Residue

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Changjin Zhu, Takaaki Ohashi, Tatsuya Morimoto, Arnold N. Onyango, Kaneko Takao, Sakayu Shimizu, Shuhei Nakajima and Naomichi Baba


Abstract

2-(15′-Oxo-5′,8′,11′,13′-eicosatetraenoyl)-1-stearoyl-sn-glycerol(3)phosphocholine (APC-CO) 1 and 2 and 2-(13′-oxo-9′,11′-octadecadienoyl)-1-stearoyl-sn-glycero(3)phosphocholine (LPC-CO) 3 are synthesized and an analytical system established for the determination of geometrical isomers at the 13′ position of APC-CO.


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