Lithium Perchlorate Mediated Three Component Reaction for the Preparation of Primary Amines

Abstract

In the presence of lithium perchlorate in diethyl ether, LPDE, a three-component reaction between aldehydes, sodium hexamethyldisilazane or lithium hexamethyldisilazane, LHMDS, and different nucleophiles proceeds smoothly to afford primary amines in good yields.

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