Facile Total Syntheses of Two Novel 4-Alkenyloxy-2,6-dihydroxyacetophenones

Abstract

Two novel acetophenones, 4-(1′-geranyloxy)-2,6-dihydroxyacetophenone 1 and 4-(1′-farnesyloxy)-2,6-dihydroxyacetophenone 2 isolated from the fruit of Evodia merrillii and from the aerial parts of Borronia ramosa respectively, have been synthesized starting from 2,4,6-trihydroxyacetophenone 3; the key step in their total synthesis is the regioselective alkenylation onto the intermediate 6 with alkenyl bromide.

References

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