An Expeditious Synthesis of 4-Acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-Acyl-6-aryl-2-oxo-2,3-dihydropyrimidines

Abstract

A facile synthesis of 4-acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-acyl-6-aryl-2-oxo-2,3-dihydropyrimidines is described where the Friedel–Crafts reaction on 2,6-dichloropyrimidine-4-carbonyl chloride plays a crucial role.

References

1. T. Miyasaka, H. Tanaka, M. Baba, H. Hayakawa, R. T. Walker, J. Balzarini and E. De Clercq, J. Med. Chem., 1989, 32, 2507.
2. S. Massa, A. Mai, M. Artico, G. Sbardella, E. Tramontano, A. G. Loi, P. Scano and P. La Colla, Antiviral Chem. Chemther, 1995, 6, 1.
3. P. Das, C. P. Spears, A. H. Shahinian, S. K. Dasgupta and N. G. Kundu, Bioorg. Med. Chem. Lett., 1996, 6, 2477.
4. N. G. Kundu and P. Das, J. Chem. Soc., Chem. Commun., 1995, 99; 1995, 1195(corrigendum).
5. H. Gershon, J. Org. Chem., 1962, 27, 3507.