Utility of [(p-Sulfonamidophenyl)azo]malononitrile in the Synthesis of Polyfunctionally Substituted Pyrimidine, Pyrazole, Isoxazole and Pyridazine Derivatives

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Abu Zeid Abd El-Baset Hassanien, Ibrahim Saad Abdel Hafiz and Mohamed Hilmy Elnagdi


Abstract

[(p-Sulfonamidophenyl)azo]malononitrile and/or [(p-sulfonamidophenyl)azo]acrylonitrile derivatives react with various reagents to afford pyrimidine, pyrazole, isooxazole and pyridazine derivatives with interesting biological activities via initial addition to either the cyano or amino group followed by cyclization.


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