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DOI: 10.1039/A902524C (Paper) Reference Section for: J. Anal. At. Spectrom., 1999, 14, 1333-1337

Selenomethionine chiral speciation in yeast and parenteral solutions by chiral phase capillary gas chromatography-ICP-MS

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S. Pérez Méndez, M. Montes Bayón, E. Blanco González and A. Sanz-Medel

Abstract

Chiral resolution and speciation of DL-selenomethionine enantiomers by capillary gas chromatography (GC) as N-trifluoroacetyl (TFA)-O-isopropyl derivatives using an l-valine-tert-butylamide modified polydimethylsiloxane chiral stationary phase (Chirasil-L-Val) were investigated. Good resolution was achieved using a temperature program from 100[thin space (1/6-em)]°C (held for 3 min) to 160[thin space (1/6-em)]°C at 1.5[thin space (1/6-em)]°C min–1 and He as carrier gas. Very good selectivity and excellent detection limits of 0.25 µg L–1 (0.1 µg L–1 as Se) for each enantiomer were obtained by on-line coupling of the chiral capillary column with selenium-specific detection by inductively coupled plasma mass spectrometry (ICP-MS). Experimental parameter optimization is described in detail. This optimised GC-ICP-MS method was successfully applied to the determination of the optical purity of l-selenomethionine in commercial samples, to the determination of the enantiomeric ratio of selenomethionine in parenteral solutions used for human use and also to chiral Se speciation in selenized yeast.

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