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DOI: 10.1039/A900677J (Paper) Reference Section for: J. Anal. At. Spectrom., 1999, 14, 1673-1677

Measurement of calcium stable isotope tracers using cool plasma ICP-MS

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Kristine Y. Patterson, Claude Veillon, A. David Hill, Phylis B. Moser-Veillon and Thomas C. O'Haver

Abstract

A method for the measurement of calcium isotopes (42Ca, 43Ca, and 44Ca) using quadrupole inductively coupled plasma mass spectrometry (ICP-MS) is described. Interferences from polyatomic ions such as 12C16O2+ and 40ArH2+ at the calcium masses are greatly minimized by operating the ICP-MS in the cool plasma mode. Relative standard deviations (RSD) for the 42Ca∶43Ca and 44Ca∶43Ca ratios were found to be about 0.25%. Sample preparation involved using ammonium oxalate at a pH of 8 to separate calcium from samples such as serum, urine, feces, and breast milk. The isotope ratio measurements were used to determine fractional absorption of calcium by a lactating woman after intravenous administration of 42Ca and ingestion of 44Ca.

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