Characterisation of workers' exposure in a Russian nickel refinery

(Note: The full text of this document is currently only available in the PDF Version )

Yngvar Thomassen, Evert Nieboer, Dag Ellingsen, Siri Hetland, Tor Norseth, Jon Øyvind Odland, Natalya Romanova, Svetlana Chernova and Valeri P. Tchachtchine


Abstract

In support of a feasibility study of reproductive and developmental health among females employed in the Monchegorsk (Russia) nickel refinery, personal exposure and biological monitoring assessments were conducted. The inhalable aerosol fraction was measured and characterised by chemical speciation and particle-size distribution measurements. Unexpected findings were that: (i), pyrometallurgical working environments had significant levels of water-soluble nickel; (ii), significant exposure to cobalt occurred for the nickel workers; (iii), particles of size corresponding to the thoracic and respirable fractions appeared to be virtually absent in most of the areas surveyed. The water-soluble fraction is judged to be primarily responsible for the observed urinary nickel and cobalt concentrations. It is concluded relative to current international occupational-exposure limits for nickel in air, and because of the high nickel concentrations observed in urine, that the Monchegorsk nickel workers are heavily exposed. The implication of this finding for follow-up epidemiological work is alluded to.


References

  1. J. R. Boldt, Jr. and P. Queneau, The Winning of Nickel, Van Nostrand Co., Inc., New York, USA, 1967 Search PubMed.
  2. J. H. Tundermann, J. K. Tien and T. E. Howson, in Kirk-Othmer: Encyclopedia of Chemical Technology, ed. J. I. Kroschwitz and M. Howe-Grant, John Wiley, New York, 4th edn., 1996, vol. 17, pp. 1–17 Search PubMed.
  3. E. Nieboer and G. G. Fletcher, in Toxicology of Metals, ed. L. W. Chang, Lewis Publishers, New York, USA, 1996, pp. 113–132 Search PubMed.
  4. R. Doll (Author-in-Chief), Scand. J. Work Environ. Health, 1990, 16, 9 Search PubMed.
  5. ACGIH 1998 Threshold Limit Values for Chemical Substances and Physical Agents. Biological Exposure Indicies, American Conference of Governmental Industrial Hygienists, Cincinnati, OH, USA Search PubMed.
  6. E. Mastromatteo, Am. Ind. Hyg. Assoc. J., 1986, 47, 589 CrossRef CAS.
  7. S. Hetland, I. Martinsen, B. Radziuk and Y. Thomassen, Anal. Sci., 1991, 7(Suppl. 1), 1029 CAS.
  8. V. J. Zatka, J. S. Warner and D. Maskery, Environ. Sci. Technol., 1992, 26, 138 CAS.
  9. T. W. Clarkson, G. F. Nordberg and P. R. Sager, Scand. J. Work Environ. Health, 1985, 11, 145 Search PubMed.
  10. Environmental Health Criteria 108, Nickel, International Programme on Chemical Safety, WHO, Geneva, Switzerland, 1991 Search PubMed.
  11. V. P. Chashschin, G. P. Artunina and T. Norseth, Sci. Total Environ., 1994, 148, 287 CrossRef CAS.
  12. H. Gibson, J. H. Vincent and D. Mark, Ann. Occup. Hyg., 1987, 31, 463 CAS.
  13. E. Nieboer, in Nickel and Human Health. Current Perspectives. Advances in Environmental Science and Technology, ed. E. Nieboer and J. O. Nriagu, John Wiley, New York, USA, 1992, vol. 25, pp. 37–47 Search PubMed.
  14. P. J. Tsai, J. H. Vincent, G. Wahl and G. Maldonado, Occup. Environ. Med., 1995, 52, 793 CAS.
  15. M. A. Werner, J. H. Vincent, Y. Thomassen, S. Hetland and S. Berge, Environ. Hyg., in the press Search PubMed.
  16. M. Kiilunen, J. Utela, T. Rantanen, H. Norppa, A. Tossavainen, M. Koponen, H. Paakkulainen and A. Aitio, Ann. Occup. Hyg., 1997, 41, 167 CrossRef CAS.
  17. Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 52, Chlorinated Drinking-Water; Chlorination By-Products; Some Other Halogenated Compounds; Cobalt and Cobalt Compounds, International Agency for Research on Cancer, Lyon, France, 1991, pp. 363–472 Search PubMed.
  18. A. R. Oller, M. Costa and G. Oberdörster, Toxicol. Appl. Pharmacol., 1997, 143, 152 CrossRef CAS.
  19. I. Andersen, S. R. Berge and F. Resmann, Analyst, 1998, 123, 687 RSC.
  20. J. H. Vincent, P.-J. Tsai and J. S. Warner, Analyst, 1995, 120, 675 RSC.
  21. G. Ramachandran, M. A. Werner and J. H. Vincent, Analyst, 1996, 121, 1225 RSC.
  22. E. Nieboer, A. Yassi, A. A. Jusys and D. C. Muir, The Technical Feasibility and Usefulness of Biological Monitoring in the Nickel Producing Industry, McMaster University, Hamilton, Canada, 1984 Search PubMed.
  23. E. Nieboer, W. E. Sanford and B. C. Stace, in Nickel and Human Health. Current Perspectives, Advances in Environmental Science and Technology, ed. E. Nieboer and J. O. Nriagu, John Wiley, New York, USA, 1992, vol. 25, pp. 49–68 Search PubMed.
  24. F. W. Sunderman, Jr., S. M. Hopfner, J. A. Knight, K. S. McCully, A. G. Cecutti, P. G. Thornhill, K. Conway, C. Miller, S. R. Patierno and M. Costa, Carcinogenesis, 1987, 8, 305 CAS.
  25. F. W. Sunderman, Jr., in Nickel in the Human Environment, ed.-in-chief F. W. Sunderman, Jr., International Agency for Research on Cancer, Lyon, France, 1984, pp. 127–142 Search PubMed.
  26. M. A. Werner, Y. Thomassen, S. Hetland, S. Berge, T. Norseth and J. H. Vincent, in preparation.
  27. Tietz Textbook of Clinical Chemistry, ed. C. A. Burtis and E. R. Ashwood, Saunders, New York, USA, 2nd edn., 1994, pp. 1531–1536 Search PubMed.
  28. Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 49, Chromium, Nickel and Welding, International Agency for Research on Cancer, Lyon, France, 1990, pp. 257–445 Search PubMed.
  29. F. W. Sunderman, Jr., B. Dingle, S. M. Hopfer and T. Swift, Am. J. Ind. Med., 1988, 14, 257 CAS.
  30. F. W. Sunderman, Jr., S. M. Hopfer, K. R. Sweeney, A. H. Marcus, B. M. Most and J. Creason, Proc. Soc. Exp. Biol. Med., 1989, 191, 5 Search PubMed.
  31. U. Midtgård and M. L. Binderup, The Nordic Expert Group for Criteria Documentation of Health Risk from Chemicals. 114. Cobalt and Cobalt Compounds. Arbete och Hälsa, 1994, vol. 39 Search PubMed.
  32. K. L. McCance and S. E. Huether, in Pathophysiology: The Biological Basis for Disease in Adults and Children, Mosby, St. Louis, MO, USA, 1994, pp. 1122–1129 Search PubMed.
Click here to see how this site uses Cookies. View our privacy policy here.