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DOI: 10.1039/A803700K (Paper) Reference Section for: J. Chem. Soc., Dalton Trans., 1999, 459-466

Sequence dependence of the reactivity of histidyl containing peptides with palladium(II) and platinum(II) complex ions. An NMR study

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Panayotis Tsiveriotis and Nick Hadjiliadis

Abstract

The reactions of the pentapeptide His-Pro-Gly-Ala-His with the complex salts [Pd(dien)(D2O)][NO3]2, [Pt(dien)(D2O)][NO3]2, [Pd(en)(D2O)2][NO3]2, cis-[Pt(NH3)2(D2O)2][NO3]2, K2PdCl4 and K2PtCl4 were studied in aqueous solutions, as a function of pD, by means of 1H, 13C and 195Pt NMR spectroscopies in one and two dimensions. In order better to understand the behavior of the ternary systems of the pentapeptide with the complex ion [Pd(dien)(D2O)][NO3]2 or [Pt(dien)(D2O)][NO3]2, the reactions of the tetrapeptide Pro-Gly-Ala-His with these complexes were also studied as a function of pD. The 1H and 13C NMR assignments were made by two dimensional homo- and hetero-nuclear experiments at various pD’s for both peptides. The complexes [Pd(dien)(D2O)][NO3]2 or [Pt(dien)(D2O)][NO3]2, react with Pro-Gly-Ala-His in acidic or alkaline media respectively to form mixtures of two isomers in which histidyl imidazole co-ordinates the metal through either N1 or N3. In neutral solution, the imidazole ring bridges two Pd(dien) moieties, bound to N1 and N3. In the presence of [Pd(dien)(D2O)][NO3]2 the histidyl-5 residue of the pentapeptide behaves in the same way as the one in the tetrapeptide, whereas the histidyl-1 residue reacts in acidic media through both imidazole N1 and N3 bridging two Pd(dien) moieties. The complex [Pd(en)(D2O)][NO3]2 or K2PdCl4 reacts with His-Pro-Gly-Ala-His in strongly acidic media (pD < 1.5) to form 1∶1 adducts with the histidyl-1 residue co-ordinated selectively to the metal ion forming NH2, N3 chelates. Similar products are formed by the reaction of the pentapeptide with cis-[Pt(NH3)2(D2O)2][NO3]2 or K2PtCl4 in slightly alkaline or acidic media respectively.

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